See Ar Oh, from the blog "Just Like Cooking" just posted his attempt at explaining his research (organic synthesis) using the same restrictions. He used this website (which I suggest you waste some time on. It's fun).
Since I am always asked about my research but rarely have a good answer, I thought I would give it a try. So here it is: This is what I spend my time researching (explained using only the 1,000 most common words in the English language).
"In my job I hit very small things with light. Then they shake. Once I hit those small things with lots of light they break. My job is to watch how they break and that way I know what those very small things look like."
It's not even right anymore, but there you go. That's what I do in the lab.
Here's the original XKCD comic: